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About 1 in 8 couples in the United States experiences infertility. This number might seem high, but considering how many things need to go perfectly suitable to conceive, it’s not surprising.

There are many reasons why an individual or couple might have a hard time becoming pregnant, including factors related to ovarian health and egg quality, sperm quality (concentration, motility, shape), uterine health, and more.

For those having trouble conceiving, there are various options to seek or utilize that can help you get pregnant, some of which you can even begin to pursue on your own, like making changes to your diet and lifestyle to optimize your body for pregnancy. You can also work with your current OB/GYN or Primary Care Physician (PCP) to start with preliminary testing, such as basic ovarian reserve testing and a referral for a semen analysis.

For many looking into fertility treatments, two options become top choices to consider pursuing: intrauterine insemination (or IUI) and in vitro fertilization (or IVF).

For people struggling to conceive, an initial evaluation with a fertility specialist can help identify the root cause of infertility and factors that may be creating challenges. Reproductive Endocrinologists have extensive training and experience in evaluating problems that can interfere with conception — such as egg, sperm, uterine, or implantation issues — and are therefore best able to guide patients in choosing which treatments are best for them.

IUIs should be performed by a medical professional trained to do them. In most cases, IUIs are used in conjunction with medicated (oral pills) treatment cycles. IVF is a more involved treatment and should only be managed by an experienced reproductive endocrinologist (REI).

Below we’ll look at what IUI and IVF entail, the pros and cons of both treatments, and knowing which one is the right option for you.

What Is IUI?

IUI stands for intrauterine insemination. It involves having sperm injected into the uterus around the time of ovulation. This is done to bypass any potential cervical issues and decrease the sperm’s travel time to the egg and increase the likelihood of fertilization happening.

For whom is IUI a good option? It’s typically one of the first fertility treatments recommended for patients who have not gotten pregnant on their own within about six months to one year of trying depending on age. It’s a great option for those dealing with hormonal and fertility issues such as:

• Anovulation (lack of ovulation without help from medication)
• PCOS
• Cervical mucus problems
• Sperm quality issues
• It can also help same-sex couples using donor sperm, single mothers using donor sperm, and sometimes couples with unexplained infertility.

You might also hear IUI referred to as artificial insemination. IUI involves the sperm first being “washed” to increase its potency, then being delivered directly to the uterus.

“Washing” sperm means that a sperm sample is first collected, and then the sperm are separated to sort healthy, motile (swimming) sperm from the less healthy sperm and seminal fluid. Only the best quality sperm is used during an IUI; this way, there’s the greatest chance of the sperm being able to reach and penetrate the egg.

It’s essential that the individual is ovulating or just about to ovulate when IUI is performed because this is the only time that a person can get pregnant. Ovulation is when a mature egg is released from an ovary to begin its journey down the fallopian tubes, at which point it can be fertilized.

Before an IUI is performed, a doctor monitors the individual to track the timing of their cycle and ensure they are ovulating. Monitoring can be done using an ultrasound, which looks at egg follicles within ovaries, and sometimes with bloodwork.

Here are the basic steps involved in an IUI cycle:

• The IUI cycle begins on the first day of a person’s period and the egg(s) mature inside the ovaries for about the next two weeks leading to ovulation.
• Some people will take medications to encourage ovulation during this period. For example, medications (such as oral meds like Clomid or Letrozole or injectable hormone medications called gonadotropins) can be used to stimulate more eggs to mature and be released.
• In most cases, the IUI will take place on the day of ovulation or sometimes the day prior. This is determined using monitoring. A “trigger shot” might also be used to time ovulation since this medication induces ovulation within about 36 hours.
• A sperm sample from either a partner or a donor will be provided to the doctor’s office, then washed.
• The doctor/practitioner will insert the washed sperm sample into the uterus using a thin catheter. This is primarily painless and only takes a couple of minutes.
• After the IUI, the person will lay down and relax for about 10 minutes, and then they are free to leave the doctor’s office and go about their day. Hopefully, at this point, fertilization takes place.

What are the advantages of IUI?

Below are some of the main advantages of IUI:

• Less invasive and less expensive compared to IVF. A typical IUI cycle can cost about $1000 (depending on your insurance), while IVF can cost $20,000 per cycle.

• IUI Deposits the best quality sperm possible close to where the egg is waiting, which increases the chances of becoming pregnant in comparison to conceiving through intercourse.
• Uses monitoring to ensure that insemination happens at the time of ovulation.
• IUI cycles can either use medications or not, depending on the specific situation. Those who have difficulties ovulating, such as those with irregular periods or PCOS, can use medications to help release more mature eggs.
• Not using ovulation medication can help lower the cost. This is a good approach for those who ovulate regularly or who are using donor sperm.

Who performs IUIs?

IUIs cannot be performed at home without proper processing and washing of seminal fluid; however, some people may try intravaginal or intracervical inseminations at home, with significantly less success. Most often, people choose to see a medical professional for the procedure. OB/GYNs can perform IUI, which means patients may be able to work with their previous provider if they prefer (only reproductive endocrinologists can perform IVF, however).

That being said, patients often choose to work with a fertility specialist or an REI for an IUI because an REI can perform thorough tests prior to an IUI in order to gain more advanced knowledge of a patient’s fertility status and obstacles.

Specialists typically have cutting-edge technology and equipment and are capable of uncovering a great deal of information about the quality of one’s sperm, eggs, anatomy, menstrual patterns, and so on, which can help increase success with IUI.

How successful is IUI?

IUI is said to have “modest results” in terms of success, meaning it isn’t guaranteed to work and isn’t necessarily more successful than two healthy people having intercourse.

In best-case scenarios, it’s successful about 7% to 20% of the time per IUI cycle, depending on the woman’s age. If a couple tries IUI several times and does not have severe damage to fallopian tubes and has decent quality sperm, they may have a 50% chance of getting pregnant with up to six rounds of IUI.

Overall, success rates depend on the couple’s age, the timing of the procedure, and the health of the eggs and sperm. Individuals younger than 35 tend to have more success with IUI than those over 35 to 40 years old.

Are there any side effects of IUI?

IUI typically doesn’t hurt, although it may feel a bit uncomfortable. Some people experience mild cramping during the procedure. Afterward, it’s okay for the person to resume normal activities, as they’re unlikely to feel any significant side effects.

Side effects can be more noticeable if medications are being taken. For example, ovulation medications can sometimes cause temporary bloating, cramping, water retention, and breast pain.

There’s also a higher likelihood of having multiples (twins or triplets) if using gonadotropin medications with IUI since these drugs can cause multiple eggs to be released and potentially fertilized.

What Is IVF?

IVF stands for in vitro fertilization. It’s a fertility treatment that fertilizes eggs with sperm in a lab (“in vitro” refers to a process performed in a laboratory culture dish instead of inside the body).

IVF is one type of artificial reproductive technology (or ART). IVF aims to stimulate the ovaries to mature as many healthy eggs as possible in a given cycle in order to create embryos. In the majority of cases patients pursuing IVF choose to utilize genetic testing, which entails a few cells being removed from the embryos for testing prior to freezing. Through genetic testing, your REI physician will be able to dramatically increase the likelihood that the embryo being transferred into the uterus is genetically healthy and increase the liklihood of getting pregnant. There are many reasons individuals or couples choose to pursue IVF when growing their family, including various causes of infertility, wanting to utilize genetic testing on embryos, or moving on from other fertility treatments that have been unsuccessful.

The entire IVF process can usually occur within three months. Medications are first used to help eggs inside the ovaries mature, then as many eggs as possible are removed from the body with help from an egg retrieval procedure. The mature eggs are then mixed with a sperm sample in a lab (called insemination), hopefully facilitating fertilization and embryo formation. In frozen embryo cycles, embryos are then frozen to allow for the woman’s body to return to normal after stimulation within a few weeks. The final step is the frozen embryo transfer which occurs after the uterus is primed with estrogen and progesterone for approximately three weeks. In this minor painless procedure, an embryo is released inside the uterus with the aid of ultrasound guidance.

To summarize the steps above, a cycle of IVF includes several steps:

• Ovarian stimulation using injectable medications.
• Egg retrieval from the ovaries.
• Fertilization of retrieved eggs using a semen sample within a laboratory.​​
• Optional but recommended preimplantation genetic testing of embryos prior to freezing them.
• Uterine lining preparation.
• Transfer of the fertilized embryo back into the uterus using a thin tube through the cervix under ultrasound guidance
• Then hopefully, pregnancy occurs!

There are several additional treatment options available with IVF, including using intracytoplasmic sperm injection (or ICSI), Preimplantation Genetic Testing (PGT), or using donor eggs, donor sperm, or a gestational carrier (surrogate). Including any of these options into your treatment plan will all depend on the couple’s specific needs.

Who is IVF best suited for? Depending on the factors contributing to infertility, IVF may be the best choice and recommended as the primary treatment plan due to its significantly higher success rates than IUI. However, less aggressive initial attempts with IUI cycles would also be appropriate in many situations due to its less invasive and costly nature. In general, IVF would be a good first choice for those with the following conditions:

• Damaged, blocked, or absent fallopian tubes (the procedure bypasses the fallopian tubes, where ovulation typically takes place).
• Poor sperm quality (it can be successful even with very little healthy sperm, as explained more below).
• Prolonged unexplained infertility.
• Problems with ovulation that are not being solved with other treatments.
• Severe endometriosis
• A genetic disorder that can be passed down to offspring.

IVF With ICSI:

ICSI is a procedure only available during IVF and cannot be performed with an IUI. It involves having a single healthy sperm be injected into a mature, retrieved egg. Research shows ICSI typically fertilizes between 50% to 80% of eggs. ICSI is often recommended as a good option when undergoing IVF treatment if:

• The partner produces too few sperm to do IUI or traditional IVF (in which 50,000 sperm are used to inseminate a retrieved egg).
• Sperm aren’t motile, or sperm have trouble attaching to or penetrating the thick outer layer of the egg.
• There’s a blockage in the reproductive tract that is preventing sperm from exiting.
• Traditional IVF fertilization has not worked for unknown reasons.
• Eggs that were previously frozen are being used.

What are the advantages of IVF?

Below are some of the main advantages of IVF:

• Considered the most potent fertility treatment, it can help couples get pregnant when other options cannot.
• It can help address reproductive issues related to both egg and sperm providers, including egg and sperm health and problems with the cervix and fallopian tubes.
• It can help treat age-related infertility and prolonged unexplained infertility, which often lead to unsuccessful treatment with  IUI.
• It offers the option of using ICSI, which IUI does not.
• It offers the option of using genetic testing, which IUI does not. This reduces concerns regarding certain genetic disorders since embryos can be tested before being implanted to identify genetic disorders or chromosomal abnormalities.
• It offers the option of storing embryos to be used and transferred at another time.

Preimplantation Genetic Testing:

One of the significant advantages of IVF is that it allows for genetic testing of embryos, including for inherited familial diseases, which IUI and other fertility options do not.

Called Preimplantation Genetic Testing (or PGT), this type of testing is performed to identify if embryos have a specific genetic or chromosomal condition. This way, those embryos are not transferred to the uterus, and the defect is not passed onto the offspring. The goal is to ensure that healthy embryos are transferred to the uterus in order to sustain a pregnancy and result in a healthy baby.

PGT also helps address the fact that one of the most common reasons embryos do not transfer and result in pregnancies is because of abnormal embryo genetic factors.

PGT may be recommended for couples or patients with a history of single-gene disorders, such as cystic fibrosis or sickle cell anemia, or sex-linked disorders, such as Duchenne muscular dystrophy and Fragile X syndrome.

How successful is IVF?

IVF now accounts for up to 4.5% of all live births in the United States and Europe.

The chances of getting pregnant with help from IVF ultimately depend on a number of factors, including age and overall health status, the underlying reason for infertility, and how many healthy embryos were created.

Like with IUI, IVF is most successful when the person providing eggs is younger than 35 to 40 years old and generally healthy. Overall, women between 30 and 40 have about a 40% to 50% chance of IVF working depending on several factors, and however, with the advent of PGT testing, a genetically normal embryo would have an approximately 70% chance of resulting in a healthy pregnancy in a high-quality fertility clinic.

Are there any side effects?

IVF involves using medications that can cause side effects, such as bloating, nausea, water retention, headaches, and mood swings. These are temporary and usually last about one week or so.

The egg retrieval procedure is performed under anesthesia and takes approximately 15-20 minutes. After the process, there may be some mild discomfort, including cramping, swollen ovaries, light bleeding, and tenderness. Following IVF, patients should avoid anything too strenuous, or that involves twisting of the ovaries.

Depending on the medications used in the IVF stimulation, there may also exist a minimal risk of ovarian hyperstimulation, which is a condition that can cause the ovaries to become temporarily swollen and painful, and in very rare circumstances, requires fluid to be removed from the abdomen.

IUI Vs. IVF: Which Is Right For You?

There’s a lot to consider when deciding between IUI and IVF, including the cost, invasiveness, time commitment, use of medications, potential side effects, and success rates.

An IVF cycle is more involved, invasive, and expensive than an IUI cycle; however, it can also be significantly more successful when IUI and medications are not.

If you’re dealing with infertility, your provider will help guide you through the process.

Your fertility provider will run tests to determine things like your egg and sperm quality and then be able to advise you on options that are most likely to be successful. Because every infertility situation is unique and complex, it’s best to listen to your provider’s recommendations regarding your treatment plan.

Is it worth trying IUI before IVF?

You and your doctor together can review your current health status and the specific conditions you’re facing to determine if IUI should be performed first or if it is in your best interest to move directly to IVF as your first-line treatment choice.

In many cases, if appropriate, your physician may recommend trying up to three cycles (sometimes up to six) of medicated IUI before moving onto IVF, assuming there are no significant obstacles that can interfere with IUI being successful. Sometimes certain insurance companies will require this before paying for IVF.

Some doctors may suggest that women in their 40s only try IUI once or twice before going to IVF, or even that they go straight to IVF to not waste time.

How do you know if you should do IUI first or go straight to IVF?

According to fertility experts, here is when to consider IUI before moving on to IVF:

• Try IUI first if your infertility is mainly related to ovulation issues. This includes individuals with PCOS or other forms of anovulation, plus cervical mucus problems.
• If the partner providing sperm has moderate sperm health issues but is still producing healthy amounts of sperm, try IUI first.
• Same-sex couples and single parents trying to conceive with donor sperm can also try IUI first.
• If the egg provider is under 35 or between 35 and 40 with no significant known fertility issues, IUI is typically done before IVF.

IVF may be a better option if 3-6 IUI cycles have been unsuccessful, or if the individual providing eggs or carrying the pregnancy is in their 40s, there is very little good quality sperm, or if there are known problems with uterine or fallopian tube function.

Family planning is another crucial element to consider when deciding where to start. If more than one child is desired, and advanced female age is one of the issues, IVF may be the best option in order to provide ample opportunity for fertility preservation through embryo creation. This future planning can allow individuals and couples to build the family of their dreams instead of enduring a long fertility journey that results in a significant decrease in the chance of additional successful cycles and future children.

Don’t forget to discuss these issues with your trusted REI so they can guide you appropriately.

By The Time You’re 30, Here’s What You Should Know About Your Fertility

Many individuals are having their first child later in life than in previous generations. Therefore, it’s important for people to understand the timeline of their fertility.

In the U.S, the average age that a woman has her first child is 26, up a full five years from the average age of 21 in 1972. A growing percentage of women are choosing to wait to have children until their 30s. This is influenced by factors including demanding careers, longer times spent in college or graduate school, or getting married at a later age.

By the time you’re 30 or 35, what do you need to know about your ability to conceive and have a healthy pregnancy?

Below we’ll look at how hormones, egg count and quality, and other factors involved in reproduction change once you’re in your 30s. We’ll also cover fertility treatments most often recommended for those over the age of 35 and cover the basics of freezing your eggs.

Fertility In Your 30’s

If you recall learning about reproduction in high school biology class, you may remember that women are born with all of their eggs. Unlike men who continuously make sperm throughout their lives, women don’t make any new eggs over time. Therefore, the quantity and quality of a person’s eggs start to diminish the older they get, starting from a young age.

According to the American College of Obstetricians and Gynecologists, “Peak reproductive years are between the late teens and late 20s. By age 30, fertility (the ability to get pregnant) starts to decline. This decline becomes more rapid once you reach your mid-30s.”

By the age of 45, the average person’s ability to get pregnant naturally has substantially decreased, to the extent that they’re very unlikely to get pregnant without any intervention.

“Ovarian reserve” refers to the number of healthy, normal eggs that a woman has left inside her two ovaries. This number decreases with age. Having “diminished ovarian reserve” becomes more likely in a person’s 30s, indicating that reproductive potential is lower based on the number and quality of eggs left.

Not only does the quantity of eggs decrease over time, but egg quality also diminishes as a person gets older; remaining eggs in older women are more likely to have abnormal chromosomes compared to eggs in those that are younger.

Changing hormones and pre-existing conditions are two other fertility factors to consider during your 30s. Women in their mid to late 30s have a higher risk of having disorders that can affect a healthy pregnancy, such as uterine fibroids, ovarian cysts, endometriosis, and pelvic inflammatory disease.

Levels of estrogen, the key hormone that controls a menstrual cycle, start to decrease in your mid-30s, resulting in less regular ovulation and irregular periods. Estrogen does not control the menstrual cycle. I would say something like the incidence of ovulation dysfunction increases as we age, resulting in fewer ovulatory cycles per year and irregular periods. Some women enter perimenopause (the stage prior to menopause) as soon as their late 30s, which can make conception less likely.

Finally, although it’s usually only temporary, past birth control use can also impact fertility, especially birth control forms such as injectables/shots. It can sometimes take up to 18 months for ovulation to resume once stopping birth control injections, which is something to take into account if you currently use birth control and wish to get pregnant in the near future.

Success Rates of Getting Pregnant

The average 30-year-old woman without any preexisting reproductive conditions has about a 20% chance of getting pregnant each month. In comparison, someone in their 20s has an even greater chance, about 25% per month.

By the time a woman reaches 40, the success rate of getting pregnant naturally drops to about 5% per month, meaning about one or two out of 10 would be able to get pregnant each month when actively trying to conceive.

Once an individual reaches their mid-30s, the older they get, the higher the risk of having a miscarriage or having a baby with fetal abnormalities. It’s estimated that about 15% of pregnancies in those under 35 result in miscarriage, but this number increases up to 25% to 50% if the person is between 39 and 44 years old.

Other factors to consider are the increased likelihood of chromosomal abnormalities, including Down syndrome, the most common chromosome problem that occurs among women who have children in their 40s. Down syndrome affects about 1 in 85 fetuses if the mom is 40 or about 1 in 35 if the mom is 45.

There are also increased maternal risks involved in having a baby at a later age, including preeclampsia (high blood pressure during pregnancy that can lead to organ injury). Older people pursuing pregnancy also have a higher chance of having twins/multiple pregnancies since the ovaries are more likely to release more than one egg per month.

Fertility Treatments Available

Tracking Your Cycle

If you’re in your 30s and trying to conceive, first start by tracking your menstrual cycles to get an understanding of how regular your periods are and when you’re most likely ovulating.

You can use any number of fertility apps on your phone to help you track your cycles, plus ovulation strips to help you pinpoint which days are best for having sex (a strip will turn positive 24 to 36 hours before ovulation, indicating to have sex at that time).

Additionally, you can monitor changes in your cervical mucus and basal body temperature to determine if and when you ovulated, which is helpful for predicting the following month’s cycle.

Visiting A Reproductive Endocrinologist (REI)

If you haven’t conceived on your own after trying for 6 to 12 months, it’s best to visit a healthcare provider for help with an infertility evaluation.

How long should you wait before seeking professional help?

Once you’re in your mid-30s, it’s recommended that you meet with a Reproductive Endocrinologist (REI) sooner rather than later. The recommended point is after about 6 months of trying on your own. REI fertility specialists can help pinpoint any fertility issues that may make conception more challenging.

REIs perform extensive exams and tests to uncover the full picture of a patient’s reproductive health, including a pelvic ultrasound (which can spot issues such as endometriosis or ovarian cysts), tubal evaluation, ovarian reserve testing, hormonal panel tests, and semen analysis for a partner.

Based on test results, your REI can help you decide which treatment options are most likely to be successful. Treatment for infertility, including if it’s related to advanced age, always depends on the individual case, as there are many potential pathways to having a successful pregnancy.

Potential fertility treatments that may be used to help you get pregnant in your 30s or 40s include IUI (most often for women under 35), IVF, or use of donor eggs, donor sperm, or possibly a gestational carrier (surrogate) if necessary.

Assisted reproductive technologies, including in vitro fertilization (IVF), can help with a variety of infertility causes that come into play in your late 30s or 40s, such as damaged or absent fallopian tubes, genetic abnormalities of embryos, low ovarian count, or a partner with low sperm quantity or quality.

Your REI can also perform prenatal and diagnostic screening tests, both before you become pregnant and once you’re pregnant, to assess the risk of birth defects or genetic disorders, including those that are more common in later-age pregnancies.

Keep in mind that no matter how you plan to become pregnant, and no matter the age, it’s important to take care of your body holistically — by maintaining a healthy weight, eating a nutrient-dense diet, quitting smoking, exercising enough, and managing stress.

Freezing Your Eggs

Egg freezing (fertility preservation) may be a good option for women in their 30s if they want to build their families later in life.

Also called oocyte cryopreservation, egg freezing essentially pauses the progression of chromosomal abnormalities that eggs experience past a certain age. This option allows women to preserve higher-quality eggs that are more likely to be chromosomally normal so that they can get pregnant at a later age through IVF.

Egg freezing can result in a lower risk of miscarriage and a lower risk of Down’s syndrome. One drawback is that it can be expensive and somewhat invasive, considering it involves many of the same medications and steps as IVF; however more employers and insurance companies are beginning to cover some costs of egg freezing.

If egg freezing seems like it may be a good fit for you, speak with your OB-GYN or an REI to discuss your future family building plans and next steps that will help you prepare as best as possible.

Going through fertility treatment, you may wonder about the best path to self-care during IVF, especially as embryo transfer day approaches. You may be worried about what effect your actions can have on the process, and you want to make sure you do everything in your power to ensure success. The good news is that caring for yourself before and after your embryo transfer procedure isn’t complicated.

Here are ten simple tips for taking care of yourself during this exciting time.

1. Eat a Healthy Diet and Stay Hydrated

If you already eat wholesome meals, keep it up. Now is the time to cut down on sweets, reduce alcohol, and add more fruits, vegetables, and lean protein. There’s no “embryo transfer diet” to follow, but eating as if you’re already pregnant is a good idea. Drinking fluids is also crucial since proper hydration is essential to optimal cell functioning. You want your body to be in optimal condition.

2. Take a Prenatal Vitamin (and Make Sure You Get Enough Folic Acid)

Now is a good time to start taking a prenatal vitamin — following your doctor’s instructions. If you’re taking an over-the-counter prenatal rather than a prescription brand, ensure that it includes DHA omega 3, vitamin D, calcium, and folic acid. While most prenatal vitamins contain adequate amounts of folic acid, your doctor may recommend an additional supplement. Folic acid helps prevent neural tube defects in your baby and may also reduce the risk of heart defects.

3. Avoid Chemical Exposure from Everyday Sources

Modern life is full of products containing endocrine-disrupting chemicals or EDCs. These chemicals may interfere with your hormones, and some can cross the placenta and build up in your unborn baby’s bloodstream, causing developmental issues. Become a label reader and avoid products that contain the following:

• Bisphenol A (BPA, common in plastics)
• Phthalates
• Parabens (common in cleaning and personal care products such as shampoo)
• Triclosan (found in anti-bacterial products).

Avoid EDCs both before and after embryo transfer or, better yet, cut them out of your life entirely.

4. Take it Easy on Transfer Day and Immediately After

While there’s certainly no need for bed rest (the embryo isn’t going to fall out, after all), relaxing and pampering yourself on embryo transfer day and for a couple of days after is a good idea. This is as much for psychological and emotional reasons as for physical ones; post-transfer days can be an emotional rollercoaster, and rest, relaxation, and pampering can go a long way toward reducing stress.

5. Relax — but Not in the Hot Tub

While pampering yourself in the days after an embryo transfer can be good for your mental and physical health, avoid the sauna or jacuzzi, and pass on a long soak in a hot bath for a few days. Some research suggests that activities that elevate your core temperature might interfere with implantation. Just to be safe, stick to showers or warm baths rather than turning up the heat.

6. Keep Taking Your Medications

Unless your doctor advises you differently, continue taking your prescribed medication. Progesterone is vital as it helps the embryo implant and ensures it stays implanted. Don’t stop any medicines unless your doctor recommends a break.

7. Abstain from Sex Until Your Doctor Okays It

If your doctor has suggested that you refrain from sexual intercourse for a short time after the embryo is transferred, you may wonder why. The answer? Sex can cause uterine contractions. This can affect the embryo’s ability to implant and, in a worst-case scenario, could theoretically lead to a miscarriage. Most experts agree that abstaining from sex for 10 to 14 days is sufficient.

8. Pay Attention to Your Body

You know your body best, so pay close attention to what it’s telling you. If anything feels wrong or “off,” inform your doctor immediately. There’s probably nothing to be concerned about, but a quick consultation can relieve your mind.

If you’ve been taking fertility drugs, keep your eye out for the following symptoms:

• Sudden weight gain
• Abdominal pain
• Bloating
• Nausea
• Vomiting
• Diarrhea

These can be symptoms of ovarian hyperstimulation syndrome or OHSS, and it’s important to let your doctor know immediately.

9. Don’t Rush Out and Buy a Pregnancy Test

Taking a pregnancy test too early isn’t a good idea, no matter how tempting it may be. Pregnancy tests measure the amount of pregnancy hormone in your urine, and it takes some time for this hormone to build up to measurable levels. You might get a false-negative or even a false-positive result if you take a test too soon. So, settle in with a stack of good books, binge-watch Netflix, or find another way to pass the time until your scheduled pregnancy test with your fertility doctor.

10. Use Stress-Reduction Tools to Make the Wait Easier

Finally, do what you can to de-stress while you’re waiting. This is a good time to sign up for meditation, a beginner’s yoga class, or embark on a stress-reduction course.

The Takeaway

The time before and after your embryo transfer can be a template for how you plan to advance during your pregnancy. Forming good habits now and learning to care for yourself with compassion can create a firm foundation to build on in the future. If you’re just starting your fertility journey, if you have questions, or if you simply want to learn more, we can help.

Contact Reproductive Gynecology and Infertility today and speak to one of our fertility experts.

Fertility treatments such as in-vitro fertilization and egg donation (egg donor IVF or donor egg IVF) allow many individuals and couples to start or expand their family size regardless of their fertility and health status. A 2016 Center for Disease Control and Prevention survey revealed that donor eggs were used in 24,300 Assisted Reproduction Technology (ART) cycles.

Although the success rate of donor egg IVF procedures varies, the average success rate of live births utilizing this procedure is 49-50%. Your odds of succeeding in using donor eggs are higher when you follow specific steps and consult a fertility specialist. Our team has compiled a few guidelines to help you with the donor egg IVF procedure.

This article will teach you more about egg donor IVF, the process of how donor eggs and IVF work, and the procedure’s benefits and success rates.

What is Egg Donation?

Egg donation is the process in which a donor (female) contributes her eggs to a recipient for conception purposes. At RGI, our egg donors undergo thorough physical and psychological screenings. These screening tests help to ascertain the egg donor’s health status and suitability for the egg donation journey before matching with recipients.

After an egg donor passes the critical screening steps to confirm their eligibility, she will undergo the process to retrieve eggs. First, the donor will take medication to stimulate the ovaries to produce multiple eggs. Egg donors then undergo an egg retrieval to obtain the eggs available for use by another individual or couple.

Eventually, the eggs are fertilized in the lab through in vitro fertilization. In vitro fertilization is the process in which the eggs are exposed to sperm resulting in the development of an embryo in a culture medium in the laboratory. This embryo will then be placed in the recipient’s uterus to result in pregnancy.

Who Benefits From Egg Donation/Donor Egg?

The egg donation process is suitable for individuals and couples who want to start a family but cannot for various reasons.

The egg donation process is recommended in the following clinical cases:

• older females with infertility
• single males who have a gestational carrier (surrogate)
• gay male couples
• those with a high risk of transmitting a genetic disease
• females with low ovarian reserves and primary ovarian insufficiency
• females with damaged ovaries due to cancer treatment
• unexplained recurrent IVF failure

Apart from these indications, the fertility doctor will evaluate your unique health needs to determine if you will benefit from egg donation.

What Is the Process of Egg Donation?

Pre-donation Screening

Fertility doctors use specific guidelines stipulated by the law to screen egg donors in a fertility clinic. U.S. Food and Drug Administration (FDA) guidelines recommend the following screening procedures for egg donors:

The egg donation process occurs in phases and has both medical and legal procedures to protect the donor and recipient. Here are the typical steps of the egg donation process.

• formal application
• in-person or phone interview
• clinical and psychological history to discover the donor’s medical and family history
• physical examination
• blood tests such as HIV, etc, for infectious disease screening
• drug tests
• ultrasound scan to examine the female reproductive organs
• genetic testing to screen for inherited disease

These screening procedures help to confirm the eligibility and health status of the prospective egg donor.

Legal Procedure

The law regulates the egg donation process and helps to protect both parties involved. Generally, the donor and recipient may opt for legal counsel before the egg donation process. Sometimes, a lawyer helps mediate the legal procedures, such as verifying and witnessing contract signing. For instance, some egg donation clinics require all donors to sign a contract. This contract will typically state that the donors do not have any legal rights or responsibilities to a child resulting from the process.

The Treatment Phase

The fertility specialist will use specific fertility drugs to prepare the egg donor. While on these medications, fertility experts monitor the donor closely, stimulating her ovaries to make several eggs in a single cycle. Once the ovaries appear ready, a medication to induce the maturity of the eggs is administered at a precise time relative to the egg retrieval procedure. During this phase, egg donors remain abstinent from sexual intercourse to eliminate pregnancy risk for the egg donor.

Egg Retrieval

On the retrieval day, the donor will receive anesthesia medications, often through the IV. Then the doctor will use ultrasound guidance to insert a needle through the vagina and into the ovary to extract the eggs from the matured follicles. Extracted eggs are cryopreserved until they are used by a recipient for in vitro fertilization.

How Do Donor Eggs and IVF Work?

The in vitro fertilization process takes place after eggs are retrieved from the donor. The sperm donor or intended parent will provide the semen specimen, which will be used to fertilize the mature eggs.

Fertilization can occur in two ways;

• Conventional insemination: Healthy matured eggs are exposed to sperm cells in the culture medium to allow fertilization.
• Intracytoplasmic sperm injection (ICSI). In ICSI, a sperm cell is injected directly into each mature egg. ICSI is ideal for clinical cases of low sperm count or repeated history of failed IVF.

After successful fertilization, the embryo grows in the culture medium in the lab. The fertility expert transfers the embryo into the intended parent or gestational carrier’s uterus for implantation.

How Much Do Donor Eggs and IVF Cost?

The cost of egg donation varies depending on the source of the donor eggs. Couples can get egg donors from the following sources:

• Egg donor agencies: These are specialized commercial egg donation agencies that recruit, screen, and match healthy egg donors with interested couples.
• Infertility clinics: Some have a bank of frozen eggs harvested from past clients.
• Specific individuals: A couple can choose a close relative or friend as their egg donor.

The cost of the invitro fertilization process differs for each fertility clinic. The average cost of egg donation will range between $10,000- $15,000. This could be more if it is a fresh egg donation process versus frozen donor eggs, which are typically less expensive.

According to the American Society of Reproductive Medicine, the average cost for one in vitro fertilization (IVF) cycle is more than $12,000. This cost is in addition to the cost of an egg donor.

What Are the Success Rates of Donor Egg + IVF?

The success rate of egg donation and in vitro fertilization differs from clinic to clinic. The recent Center for Disease Control fertility report states that close to 50% of donor eggs and in vitro fertilization result in a live birth.

The success rate of egg donation and IVF also depends on the following:

• egg donor’s age
• extraction process
• quality of sperm,
• recipient’s health status

Hence, it is important to consult a fertility expert with a proven track record of successful egg donation and IVF.

Do You Need Help With Egg Donation and IVF?

Egg donation and IVF help couples to start or expand their family size regardless of their health or fertility status. Egg donation and IVF are safe and suitable for LBGTQ+ couples and heterosexual couples struggling with fertility. The egg donation process involves multiple steps and requires expert guidance from an experienced team of fertility experts.

At Reproductive Gynecology and Infertility, we have years of experience helping build families through IVF and donor eggs. Our state-of-the-art IVF technology solution has helped partners achieve their dreams of having a beautiful family.

We have a team of industry-leading fertility physicians and assisted reproductive technology professionals to assist you. Schedule an appointment with us to get started on your family-building journey.